![]() Intravenous vitamin K reduced INR more rapidly than oral vitamin K (5.09, 1.91, 1.54, and 1.41 vs 5.67, 2.90, 2.14, and 1.58) at baseline, 12, 24, and 48 hours, respectively. Data collected included international normalized ratios (INRs) 12 hours, 24 hours, and 48 hours prior to vitamin K administration intravenous or oral vitamin K dose and whether or not fresh frozen plasma (FFP) was administered. This was a chart review of 400 patients who received vitamin K for reversal of warfarin effects between February 2008 and November 2010. To determine factors influencing the extent and rate of INR reversal with vitamin K in the acute/critical care setting. ![]() However, the optimal dose and route of vitamin K that does not increase the duration of bridging therapy is unknown. Vitamin K is commonly used for reversal of anticoagulation of warfarin. ![]()
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